The University of Perpetual Help System, having committed itself to service in the forefront of education and health care, came into being out of the unselfish effort and untiring commitment of its founder: Dr. Jose G. Tamayo and Dr. Josefina Laperal Tamayo. The desire to serve others was manifested at a very young age when Dr. Jose G. Tamayo, then a young boy dreamt of being a doctor. For him, it was the best way he that he could serve his fellowmen. But when that dream became a reality, he realized that his best was not good enough the services he rendered were so limited and only within the realm of his profession as a doctor. With an ardent desire to serve his fellowmen, the idea of reaching out to through the setting up of an educational institution, gave birth to the following:

Perpetual Help College Manila. Opened in 1968 with Nursing as key a course offering. Most graduate are now in the USA who formed themselves into Perpetualites Association of America and serving as a direct linkage for Perpetualite students and alumni there.

Perpetual Help College Malasiqui Located in the heart of Municipality of Malasiqui , Pangasinan, it was founded in 1970 to accelerate the development of health education in the rural areas particularly in the Province of Pangasinan. University of Perpetual Help Rizal (formerly

Perpetual Help College of Rizal). In 1975, the eldest son, Antonio, inspired by his parents, spearheaded the founding of another school in the City of Las Piñas. The Molino Campus in Bacoor, Cavite and Calamba Campus in Laguna are extension programs of University of Perpetual Help Rizal , which started their operations in 1996 and 1997 respectively.

University of Perpetual Help System Laguna (formerly Perpetual Help College of Laguna) opened its door for academic excellence in 1976 with a total of 89 students in the first and second and 367 students in the tertiary level. The campus is located along the old national highway in Biñan which is very accessible.

University of Perpetual Help System – GMA Campus started its operation in 1997 UPH-Dr. Jose G. Tamayo Medical University formed in 1976, specializing in medical and health related courses and also located in Biñan, Laguna.

University of Perpetual Help System Laguna-Isabela Campus is the youngest satellite of the university system. It aims to provide the northern part of the country an avenue to bring out the nurture the seeds of excellence through Perpetualite education.

The University of Perpetual Help System is dedicated to the development of the Filipino as a leader. It aims to graduate dynamic students who are physically, intellectually, socially and spiritually committed to the achievement of the highest quality of life.

As a system of service in health and education, the University of Perpetual Help System is dedicated to the formation of Christian service and research-oriented professional, leader and citizen with great social concern and with commitment to the delivery of quality education and health care.

It shall produce Perpetualites who outstandingly value the virtues of reaching out and helping others as vital ingredients to nation building.

The University of Perpetual Help System shall emerge as the premiere university South of Metro Manila and in the Southern tagalong Region. Is shall provide a venue for pursuit of excellence in academics, technology, and research through community partnership.

Specifically, the university shall take the role of a catalyst for human development. It shall continue to inculcate values as a way of strengthening the moral fiber of the Filipino individual, proud of their race and prepared for exemplary global participation in the arts, sciences, humanities and business.

It foresees the Filipino people enjoying a quality of life and abundance, living in peace and building a nation that the next generation will nourish, cherish and value.